New research: Opioids not as effective as acetaminophen-ibuprofen

April 8, 2025
A recent study of 1,800 patients who had third molar extractions found that those who received a combination of acetaminophen and ibuprofen had better pain relief through days one and two postsurgery than the patients who received hydrocodone and acetaminophen.

What’s this we’re hearing about opioids not being as effective as the combination of acetaminophen and ibuprofen?

A randomized Rutgers health study of 1,800 patients who had third molar extractions found that patients who received a combination of acetaminophen and ibuprofen had better pain relief through days one and two postsurgery than the patients who received hydrocodone and acetaminophen. At no time was the hydrocodone considered better than the acetaminophen-ibuprofen combo.

Opioids still have a place in dentistry, but they are an “escape strategy.” Opioids don’t treat pain; they just postpone it.

Join us in this episode of Medical History Mysteries as we talk about this latest study and best practices for pain relief in dental patients.

Thumbnail image credits simarik / E+ / Getty Images

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Editor’s note: This article first appeared in Clinical Insights newsletter, a publication of the Endeavor Business Media Dental Group. Read more articles and subscribe.

About the Author

Pamela Maragliano-Muniz, DMD

Pamela Maragliano-Muniz, DMD, is the chief editor of DentistryIQ and editorial co-director of Through the Loupes. Based in Salem, Massachusetts, Dr. Maragliano-Muniz began her clinical career as a dental hygienist. She went on to attend Tufts University School of Dental Medicine, where she earned her doctorate in dental medicine. She then attended the University of California, Los Angeles, School of Dental Medicine, where she became board-certified in prosthodontics. Dr. Maragliano-Muniz owns a private practice, Salem Dental Arts, and lectures on a variety of clinical topics. You may contact her at [email protected].

Related:

Pamela Maragliano-Muniz, DMD, named chief editor of DentistryIQ

About the Author

Tom Viola, RPh, CCP

With more than 30 years’ experience as a board-certified pharmacist, clinical educator, professional speaker, and published author, Tom Viola, RPh, CCP, has earned the reputation as the go-to specialist for making pharmacology practical and useful for dental teams. He is the founder of Pharmacology Declassified and is a member of the faculty of more than 10 dental professional degree programs. Viola has contributed to several professional journals and pharmacology textbooks, and currently serves as a consultant to the American Dental Association’s Council on Scientific Affairs.